Severity of Acute Kidney Injury and its Effect on Outcome in Patients of Dengue Virus Infection

Abstract

Background: Dengue fever is a mosquito borne viral illness that has endangered a vast population of tropical and sub-tropical areas. Dengue has multi-system involvement including liver, hematological, respiratory and central nervous systems. Spectrum of renal disorders is least studied in dengue infection and its presence in dengue may be linked to increased morbidity and mortality.

Objective: To find the frequency of acute kidney injury (AKI), its stages of severity and to compare the frequency of mortality and morbidity in various stages of AKI among dengue patients.

Study type, settings & duration: This cross sectional study was conducted at Multan Institute of Kidney Diseases, Multan from May 2019 to October 2019.

Methodology: Data of ninety patients was retrieved from hospital medical record system through non-probability consecutive sampling technique. Male and female patients of 15-50 years age with dengue virus infection were included in the study as per operational definition. Patients diagnosed with chronic kidney disease (CKD) and diabetes mellitus on the basis of history and medical record were excluded. Record of serum creatinine done at the time of admission, 48 hours later and seven days after hospital admission was taken. Presence and severity of AKI were classified according to acute kidney injury network (AKIN) criteria into stage-I, stage-I and stage-III AKI. Outcome was categorized as morbidity of patients having persistent renal dysfunction manifested by serum creatinine > 1 mg/dl assessed 7 days after admission and number of patients who died within 7 days of hospital admission. SPSS 16.0 version was ..............