The Role of Probiotics, Prebiotics and Synbiotics on Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome is a heterogeneous and multifactorial endocrine condition among women of childbearing age impeding infertility. The global prevalence of PCOS varies between 6-26%. Typical symptoms include hyperandrogenism, hyperinsulinemia, hirsutism, and ovarian dysfunction. This article reviews the effects of probiotics, prebiotics, and synbiotics supplementation on females suffering from PCOS keeping in view the most recent findings. Data was collected from 7 databases from the literature published until June 2023. The MeSH nomenclature was used in the search approach. After reviewing all the collected studies, 7 studies were selected for the review. Recent studies have proposed the association of PCOS pathogenesis with dysbiosis of gut microbiota. The use of pro, pre, and synbiotics has shown improvement in the symptoms by restoring the balance of gut microbiota. Among the many available probiotics, lactic acid-producing bacteria, e.g. L. plantarum HL2 and CCFM1019, B. lactis, and B. longum HB3 have been reported to be the most useful probiotics.