Epidemiology, Clinical Characteristics and Outcome of COVID-19 in Pediatric Patients Admitted at Aga Khan University Hospital, Karachi

    Falak Abro(1*), Javairia Khalid(2), Fariha Shaheen(3), Naureen Lalani(4), Ali Saleem(5), Fyezah Jehan(6)

Abstract

Background: The information on the epidemiology, clinical spectrum, and outcome of COVID-19 in children of developing countries are limited.

Objective: To identify the epidemiology, clinical characteristics of patients and outcome of COVID-19 in pediatric patients admitted to the Aga Khan University Hospital in Karachi, Pakistan.  

Study type, settings & duration: A retrospective study through medical records was conducted at Aga Khan University Hospital, Karachi from March to August 2020.  

Methodology: The medical record of sixty pediatric patients was used for this study. They all were positive SARS-CoV-2 by reverse transcription-polymerase chain reaction assay (RT-PCR) and were subsequently admitted at Aga Khan University Hospital Karachi, from March 2020-August 2020,and the data were analyzed using SPSS version 22.

Results: From a total of 415 suspected COVID-19 children, 60 were COVID-19 positive. Of whom, 42 (70%) children were female. About 24 (40%) children acquired COVID-19 infection through household contacts. Eight children (13.3%) were asymptomatic, whereas 35 (58.3%), 12 (20%), and 5 (8.3%) had a mild, moderate, and severe infection respectively. Respiratory symptoms were prevalent in 21 (40%) patients including pneumonia 5 (10%) and acute respiratory distress syndrome (ARDS) 3 (6%). Malignancy 7 (11%) was the most prevalent underline comorbidity. Mortality was observed in 5 (8.3%) children. Most children, 52 (87%), were discharged after a four-day median hospital stay (range 2-8 days).

Conclusion: Children with COVID-19 had mild illness. Severe illness was observed in young children and those with comorbidities. Most of the children had a good outcome with early discharge from hospital.

Keywords: Children, COVID-19, disease severity, respiratory virus, developing country

(1) Department of Pediatrics and Child Health, Aga Khan University, Karachi.
(2) Department of Pediatrics and Child Health, Aga Khan University, Karachi.
(3) Department of Pediatrics and Child Health, Aga Khan University, Karachi.
(4) Department of Pediatrics and Child Health, Aga Khan University, Karachi.
(5) Department of Pediatrics and Child Health, Aga Khan University, Karachi.
(6) Department of Pediatrics and Child Health, Aga Khan University, Karachi.
(*) Corresponding Author
Published
2021-10-25
How to Cite
Abro, F., Khalid, J., Shaheen, F., Lalani, N., Saleem, A., & Jehan, F. (2021). Epidemiology, Clinical Characteristics and Outcome of COVID-19 in Pediatric Patients Admitted at Aga Khan University Hospital, Karachi. Pakistan Journal of Medical Research, 60(3), 98-103. Retrieved from https://pjmr.org.pk/index.php/pjmr/article/view/231