Comparing the Efficacy of Intralesional Verapamil Hydrochloride vs Triamcinolone Acetonide in Treatment of Keloids/ Hypertrophic Scars

    Rozeena Tumrani(1*), Malik Muhammad Hanif(2), Tahir Hassan(3), Nazia Hanif(4)

Abstract

Objective: To compare the mean VSS score of intra lesional Verapamil Hydrochloride vs Triamcinolone Acetonide in treatment of keloids/ hypertrophic scars.

Study type, settings & duration: This non randomized controlled trial was conducted in Sheikh Zayed Hospital, Rahim Yar Khan from July 2019 to June 2020.  

Methodology: In this study the cases of either gender and age more than 12 years were included irrespective of duration of keloid via non probability consecutive sampling. A total of 100 cases were included. The cases were divided into two equal groups by lottery method. The cases in group A were treated with intralesional Triamcinolone (40mg/ml) while group B was treated with intralesional Verapamil (2.5mg/ml).In both groups, session was repeated every 3 weeks for a maximum of 8 sessions or until complete flattening of the scar. Patients were accessed on the basis of Vancouver scar scale (VSS). VSS score was compared between both groups pre and post treatment.

Results: The mean age in group A and B was 22.16±9.01 vs. 22.68±8.93 years respectively (p =0.49). The mean duration of keloid or scar was 6.58±1.54 months in group A and 6.46±1.42 in group B with p =0.31.VSS score after treatment was 2.41±1.19 vs 1.65±0.93 with respect to change in Pliability score and it was 1.61±0.81 vs 1.25±0.72 in terms of height in Verapamil vs Triamcinolone group with p values of 0.05 and 0.04 respectively.

Conclusion: There is statistically significant difference in Triamcinolone group with respect to change in Pliability score and height as compared to......

Keywords: Keloid, triamcinolone, verapamil, VSS

(1) Department of Dermatology, Sheikh Zayed Medical College/ Hospital, Rahim Yar Khan.
(2) Department of Dermatology, Sheikh Zayed Medical College/ Hospital, Rahim Yar Khan.
(3) Department of Dermatology, Sheikh Zayed Medical College/ Hospital, Rahim Yar Khan.
(4) Department of Dermatology, Sheikh Zayed Medical College/ Hospital, Rahim Yar Khan.
(*) Corresponding Author
Published
2022-05-12
How to Cite
Tumrani, R., Hanif, M. M., Hassan, T., & Hanif, N. (2022). Comparing the Efficacy of Intralesional Verapamil Hydrochloride vs Triamcinolone Acetonide in Treatment of Keloids/ Hypertrophic Scars. Pakistan Journal of Medical Research, 61(1), 15-18. Retrieved from https://pjmr.org.pk/index.php/pjmr/article/view/124