TY - JOUR AU - Bhatti, Arsalan Iqbal AU - Butt, Nauman Ismat AU - Zahoor, Muhammad Asif AU - Ashfaq, Fahmina AU - Aftab, Sabeen AU - Tareen, Muhammad Qasim PY - 2022/08/16 Y2 - 2024/03/29 TI - Prevalence of MDR-TB in Patients of Pulmonary Tuberculosis at a DHQ Hospital JF - Pakistan Journal of Medical Research JA - PJMR VL - 61 IS - 2 SE - Original Articles DO - UR - https://pjmr.org.pk/index.php/pjmr/article/view/309 SP - 52-55 AB - <p><strong>Objective: </strong>The objective of this study was to determine the prevalence of MDR-TB in patients clinically diagnosed as pulmonary tuberculosis.</p><p><strong>Study type, settings &amp; duration:</strong> This descriptive cross-sectional study was conducted at tuberculosis clinic, Chest Medicine Department at DHQ Hospital Khanewal in collaboration with Department of Microbiology, Government College University Faisalabad from February 2020 to October 2020. &nbsp;</p><p><strong>Methodology: </strong>After taking informed consent, 200 clinically diagnosed pulmonary tuberculosis patients were included. Demographic data was recorded and 3 early morning sputum samples were obtained from each patient to be assessed by GeneXpert-PCR. For statistical analysis, SPSS Version 20 was used. For quantitative variables, mean ± SD were calculated. For qualitative variables, percentages and frequencies were calculated. Effect modifiers and confounders were controlled through stratification and chi square test applied with <em>p</em>-value ≤0.05 significant.</p><p><strong>Results:</strong> Mean age was 46±11.3 years with 104 (52.0%) males. Seventy-three (36.5%) were urban residents while 127 (63.5%) belonged to rural areas. Regarding sample consistency, 107 (53.5%) were mucopurulent, 34 (17.0%) purulent and 59 (29.5%) salivary consistency. Using GeneXpert-PCR, 80 (40.0%) patients were positive for tuberculosis. Rifampicin resistance was seen in 9 (4.5%) patients.</p><p><strong>Conclusion:</strong> More than two-third patients (40.0%) tested positive for tuberculosis using GeneXpert-PCR and rifampicin resistance was seen in 4.5%. It is important to diagnose such infections timely and to check anti-mycobacterium drug statuses for its treatment to prevent excessive use of drugs and to reduce disease morbidity and mortality.</p> ER -